apalutamide will lessen the extent or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medicines which have been CYP2C19 substrates may lead to reduced exposure to those remedies.
Read the Guidance for Use for specific details about the appropriate approach to use VALTOCO. Use VALTOCO precisely as prescribed by the Health care provider. Your Health care service provider will let you know: What seizure clusters are Just the amount VALTOCO to offer When and the way to give VALTOCO What to do Once you give VALTOCO if the seizures don't prevent or There exists a adjust in respiration, conduct, or problem that problems you You ought to carry VALTOCO along with you in the event you have to have to manage your seizure clusters.
Paradoxical reactions may possibly come about together with hallucinations, intense actions, and psychoses; dinscontinue use if reactions occur
For people using treated far more commonly than proposed, to reduce threat of withdrawal reactions, use a gradual taper to discontinue therapy (a individual-particular approach should be accustomed to taper the dose)
Call for unexpected emergency assistance if any of the next transpire: Seizure cluster actions is different than other seizure clusters the person has had.
darifenacin will enhance the degree or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
nevirapine will decrease the extent or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Abuse and misuse of benzodiazepines usually (although not always) involve utilization of doses bigger than the maximum advisable dosage and typically contain concomitant usage of other remedies, Liquor, and/or illicit substances, and that is connected with a heightened frequency of great adverse outcomes, like respiratory depression, overdose, or Dying
Cessation of benzodiazepines or other CNS depressants is preferred normally. In some instances, monitoring at an increased level of care for tapering CNS depressants could be acceptable. In Other folks, gradually tapering a individual off of the prescribed benzodiazepine or other CNS depressant or decreasing to the bottom successful dose could possibly more info be ideal.
VALTOCO is often a prescription medicine used for the shorter-term therapy of seizure clusters (often known as “episodes of frequent seizure exercise” or “acute repetitive seizures”) in sufferers 6 decades of age and older.
Stay clear of or substitute A different drug for these remedies when possible. Appraise for loss of therapeutic result if medication have to be coadministered.
diazepam will enhance the level or effect of flibanserin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Improved flibanserin adverse results may perhaps manifest if coadministered with many weak CYP3A4 inhibitors.
You recognize you might revoke your permission and participation in This system at any time by unsubscribing.
sage decreases outcomes of diazepam by pharmacodynamic antagonism. Slight/Significance Mysterious. Theoretical interaction; some species of sage may possibly lead to convulsions.